Pamela J McLean Selected Research

2- fluoro- 6- (tetrahydrofuran- 3- ylamino)- 4- (3,6,6- trimethyl- 4- oxo- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzamide

1/2014

Chronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell loss.

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Pamela J McLean Research Topics

Disease

68	Parkinson Disease (Parkinson's Disease) 11/2023 - 05/2002
23	Dementia (Dementias) 01/2023 - 06/2004
22	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 06/2004
19	Synucleinopathies 01/2023 - 04/2008
10	Alzheimer Disease (Alzheimer's Disease) 10/2023 - 08/2005
6	Lewy Body Disease (Lewy Body Dementia) 10/2023 - 12/2015
4	Multiple System Atrophy 01/2023 - 01/2010
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2023 - 03/2011
3	Gliosis 01/2023 - 05/2013
3	Proteostasis Deficiencies 01/2016 - 10/2014
2	Neuroinflammatory Diseases 07/2023 - 03/2018
2	Inflammation (Inflammations) 07/2023 - 01/2021
2	Rupture 01/2021 - 01/2017
2	Amyloid Plaque 08/2011 - 08/2005
2	Huntington Disease (Huntington's Disease) 12/2006 - 03/2006
1	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2023
1	TDP-43 Proteinopathies 01/2023
1	Nervous System Diseases (Neurological Disorders) 01/2023
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2023
1	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Disease Progression 01/2019
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 12/2015
1	Tauopathies 10/2014
1	Parkinsonian Disorders (Parkinsonism) 01/2014
1	Weight Loss (Weight Reduction) 01/2014
1	Gaucher Disease (Gaucher's Disease) 07/2011
1	Neuroblastoma 04/2006

Drug/Important Bio-Agent (IBA)

42	alpha-SynucleinIBA 10/2023 - 11/2002
28	SynucleinsIBA 11/2023 - 05/2002
21	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2002
3	Biomarkers (Surrogate Marker)IBA 01/2023 - 01/2016
3	Apolipoprotein E4IBA 01/2023 - 01/2020
3	Amyloid (Amyloid Fibrils)IBA 01/2022 - 08/2011
3	Dopamine (Intropin)FDA LinkGeneric 03/2018 - 09/2009
3	Molecular Chaperones (Chaperone, Molecular)IBA 12/2012 - 08/2004
2	Amyloid beta-PeptidesIBA 10/2023 - 08/2005
2	Apolipoprotein E2IBA 01/2023 - 01/2020
2	Apolipoproteins E (ApoE)IBA 01/2023 - 01/2020
2	Apolipoprotein E3IBA 01/2023 - 01/2020
2	ApolipoproteinsIBA 01/2022 - 01/2020
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020 - 11/2015
2	Peptides (Polypeptides)IBA 01/2017 - 08/2011
2	Protein AggregatesIBA 01/2017 - 02/2013
2	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2011 - 03/2011
2	UbiquitinIBA 10/2011 - 03/2011
1	DNA (Deoxyribonucleic Acid)IBA 11/2023
1	InterleukinsIBA 07/2023
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2023
1	Interleukin-6 (Interleukin 6)IBA 07/2023
1	CytokinesIBA 07/2023
1	Acetylcysteine (Siran)FDA LinkGeneric 07/2023
1	Interleukin-2 (IL2)IBA 07/2023
1	Cathepsin BIBA 06/2022
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Sirtuin 3IBA 01/2020
1	SirtuinsIBA 01/2020
1	Galectin 3 (LGALS3)IBA 01/2017
1	Superoxide Dismutase-1IBA 01/2016
1	sarkosylIBA 12/2015
1	Protein Isoforms (Isoforms)IBA 12/2015
1	Presenilin-1IBA 07/2014
1	2- fluoro- 6- (tetrahydrofuran- 3- ylamino)- 4- (3,6,6- trimethyl- 4- oxo- 4,5,6,7- tetrahydro- 1H- indol- 1- yl)benzamideIBA 01/2014
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2014
1	Contrast MediaIBA 10/2013
1	Glucosylceramidase (Glucocerebrosidase)IBA 07/2011
1	ElementsIBA 01/2011
1	Tyrosine (L-Tyrosine)FDA Link 11/2009
1	Serine (L-Serine)FDA Link 11/2009
1	Sirtuin 2IBA 07/2007
1	StaurosporineIBA 04/2006
1	Oxidopamine (6 Hydroxydopamine)IBA 04/2006

Therapy/Procedure

3	Therapeutics 05/2015 - 04/2008